Comparison of the Diagnostic Efficacy of Three Different Exponential Models in Discriminating Malignant from Benign Breast Lesions:A Study Based on Multi-b-value MUSE-DWI
Objective The objective of this study was to compare the diagnostic efficacy of three different exponential models(mono-exponential,bi-exponential,and stretched exponential)in discriminating the malignant from benign breast lesions,based on multi-b-value MUSE-DWI.Methods MRI data of 62 patients with pathologically confirmed breast diseases were retrospectively analyzed.Based on the pathological results,the lesions were divided into benign or malignant groups,and the differences between groups in the quantitative parameters of three different exponential models were compared using univariate analysis or non-parametric tests as appropriate.Binary logistic regression analysis was performed on parameters with significant intergroup differences.The DeLong test was used to compare the area under the receiver operating characteristic(ROC)curve(AUC)of the three models to evaluate the significant difference in their diagnostic efficacy.Results Intergroup comparisons showed that the values of the quantitative parameters of three different exponential models in the malignant group were lower than those in the benign group(P＜0.05).The AUC of the three models was 0.701,0.859,and 0.828,respectively.There was a significant difference in the AUC between the combined model of the parameters of the bi-exponential mode and the mono-exponential model.The diagnostic efficacy of the combined model of the parameters of the stretched-exponential model had no significant difference with the combined model of the parameters of the bi-exponential model(P=0.52)or the mono-exponential model(P=0.08).Conclusion The three exponential models(mono-exponential,bi-exponential,and stretched exponential)can help discriminate malignant from benign breast lesions.The combined model of the parameters of the bi-exponential model had better diagnostic efficacy than the mono-exponential model.
Breast LesionApparent Diffusion CoefficientBi-exponential ModelStretched-Exponential Model
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