B1 Corrected Variable Flip Angle(VFA)Sequence and Quantitative Dynamic Enhanced MRI in Benign and Malignant Breast Lesions
objective To investigate the clinical value of B1 corrected VFA and dynamic contrast enhancement(DCE)MRI in the differential diagnosis of benign and malignant breast.Methods A prospective study was conducted to analyze 63 female patients with breast diseases in our hospital,including 15 benign and 48 malignant patients.3.0 T DCE-MR was performed.Combined with B1 corrected VFA sequence,T1 quantitative parameters:volume transfer constant(Ktrans),rate constant(Kep)and extracellular space volume ratio(Ve)were measured.Kruskal-Wallis test was performed for quantitative parameters between malignant tumors,benign breast lesions and normal glands;Finally,the receiver operating characteristic curve(ROC)curve is drawn.Results The median values of Ktrans,Kep and Ve(minimum and maximum)in malignant tumor group were 0.010(0.0010.118)min1,0.145(0.002 0.863)min1 and 0.058(0.002 0.611),respectively;The median values of Ktrans,Kep and Ve in benign breast lesions were 0.238(0.009 0.740)min1,0.365(0.020 1.012)min1 and 0.517(01810.923);The median values of Ktrans,Kep and Ve in normal gland group were 0.812(0.121 2.352)min-1,1.147(0.3282.363)min-1 and 0.712(0.404 1.183).Kruskal-Wallis test showed that there were significant differences in Ktrans,Kep,Ve P＜0.05 among normal gland tissues,benign and malignant tumors;There were significant differences in Ktrans,Kep and Ve between benign and malignant lesions,malignant and normal groups,while there was no significant difference in some Ve values between benign and normal groups.The AUC of the three groups were 0.875,0.957 and 0.707 respectively,and the sensitivity of Ktrans,Kep and Ve to judge benign and malignant changes of breast were 93.8％,97.9％and 45.8％respectively;The specificity was 66.7％,86.73％and 86.7％respectively.Condusion The 3.0T DCE-MRI parameters Ktrans,Kep and Ve measured with B1 corrected VFA sequence can reflect the blood perfusion characteristics of benign and malignant breast lesions,and have certain clinical application value in the differentiation of benign and malignant breast lesions.
NETL
NSTL
万方数据
维普
