Value of Energy Spectrum CT Imaging in Evaluating Microvascular Invasion of Hepatocellular Carcinoma
Olbjective To investigate the clinical value of energy spectrum CT in the quantitative assessment of microvascular invasion(MVI)of hepatocellular carcinoma(HCC).Methods 51 patients with HCC who underwent contrast enhanced spectrum CT in arterial phase(AP)and portal venous phase(VP)were enrolled.Tumour CT value and iodine concentration(IC)were measured from spectrum CT images.The slope of spectrum curve,normalized iodine concentration(NIC)and ratio of IC difference between AP and VP(RICAP-VP)were calculated.Tumors were identified as either with or without MVI based on histopathological results.Differences between the two groups were analysed using the t-test or chi-square test,and the diagnostic performance of variables was evaluated using a receiver operating characteristic(ROC)curve.Results There were significant differences in IC,NIC and slope in AP and RICAP-VP between the groups with and without MVI(all P＜0.05).Using 3.245 as the threshold for Slope AP,one could obtain an area-under-curve(AUC)of 0.806 in ROC analysis to differentiate between tumors with and without MVI.AUC was 0.577 with CT value at 70 keV and improved to 0.757 at 40 keV.Conclusion Energy spectrum CT provides more quantitative parameters than conventional CT to facilitate the distinction between HCC with and without MVI.
Energy Spectrum ImagingContrast-enhanced Computed TomographyHepatocellular CarcinomaMicrovascular Invasion
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万方数据
维普
