Clinical Significance of Magnetic Resonance Combined with Serum KMT2D Detection in the Diagnosis of Bladder Cancer
Objective To analyze the diagnostic value of magnetic resonance combined with serum histone lysine methyltransferase 2D(KMT2D)detection in bladder cancer.Methods A total of 154 bladder cancer patients in our hospital were regarded as the bladder cancer group(BC group).According to the clinical gold standard,they were grouped into 94 cases of muscle-invasive bladder cancer(MIBC group)and 60 cases of non-muscle-invasive bladder cancer(NMIBC group).The control group consisted of 100 healthy subjects during the same period.The difference in serum KMT2D expression level in each group was compared,receiver operating characteristic(ROC)curve was used to analyze the serum KMT2D in the diagnosis of MIBC bladder cancer.The consistency of MRI,serum KMT2D and their combined diagnosis with the clinical gold standard was determined by Kappa test.Results The expression level of serum KMT2D in the BC group was lower than that in the control group,and the expression level of KMT2D in the MIBC group was lower than that in the NMIBC group(P＜0.05).The cut-off value of serum KMT2D for the diagnosis of MIBC bladder cancer was 0.68,and the area under the curve was 0.855.The MRI diagnosis of MIBC bladder cancer was in good agreement with the clinical gold standard examination(Kappa=0.730,P＜0.05).The Kappa value of MRI combined with serum KMT2D in the diagnosis of MIBC bladder cancer was 0.932 compared with the clinical gold standard results(P＜0.05).The sensitivity,accuracy and specificity of MRI combined with serum KMT2D in the diagnosis of MIBC bladder cancer were better than those of single diagnosis.Conctusion Magnetic resonance imaging combined with serum KMT2D detection has high diagnostic value for MIBC bladder cancer,which is helpful to determine the degree of bladder cancer invasion before surgery.
Magnetic ResonanceHistone Lysine Methyltransferase 2DBladder CancerDiagnosis
NETL
NSTL
万方数据
维普
