Application Value of 18F-FDG PET/CT Imaging Combined with PSMA Detection in the Diagnosis of Prostate Cancer
Objective To analyze the diagnostic value of 18F-FDG PET/CT imaging detection,prostate-specific membrane antigen(PSMA)detection and their combined detection in prostate cancer.Methods A total of 133 patients with suspected prostate cancer who came to our hospital for examination or treatment from August 2019 to August 2020 were included in this study,postoperative pathology confirmed 74 patients with prostate cancer,as the prostate cancer group,and 59 patients with benign prostatic hyperplasia,as the benign prostatic hyperplasia group,the two groups were matched for age.18F-FDG PET/CT method was performed to determine the SUVmax value of all patients,and the SUVmax value was used to determine whether the prostate cancer was negative or positive;the expression of PSMA in all patients was determined by immunohistochemistry,and PSMA positive was positive for prostate cancer;any positive result of 18F-FDG PET/CT imaging or PSMA immunohistochemical assay was judged as a positive combined diagnosis;the consistency of 18F-FDG PET/CT method,PSMA method,and their combined detection method with clinicopathological characteristics was analyzed;the four-table method was used to analyze and compare the diagnostic value of 18F-FDG PET/CT PSMA and their combined detection in prostate cancer.Results 18F-FDG PET/CT detected a total of 68 cases of prostate cancer positive and 65 cases of prostate cancer negative,of which 7 cases were misdiagnosed and 13 cases were missed,which had a high consistency with the pathological diagnosis(Kappa value=0.698,P＜0.05);PSMA immunohistochemistry detected a total of 62 cases of prostate cancer positive and 71 cases of prostate cancer negative,among them,4 cases were misdiagnosed and 16 cases were missed,which had a high consistency with the pathological diagnosis(Kappa value=0.702,P＜0.05);18F-FDG PET/CT combined with PSMA detected a total of 70 cases of prostate cancer positive and 57 cases of prostate cancer negative,of which 6 cases were misdiagnosed and 4 cases were missed,which had a high consistency with the pathological diagnosis(Kappa value=0.847,P＜0.05);the sensitivity and negative predictive value of 18F-FDG PET/CT combined with PSMA in the diagnosis of prostate cancer were higher than those of 18F-FDG PET/CT imaging or PSMA immunohistochemical detection alone(P＜0.05).Condusion The combined detection of 18F-FDG PET/CT and PSMA has significantly higher diagnostic performance for prostate cancer than 18F-FDG PET/CT imaging alone,which has a guiding role in the diagnosis of prostate cancer.
Prostate Specific Membrane AntigenProstate Cancer18F-FDG PET/CTDiagnosis
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