Predictive Value of MR Diffusion-weighted Imaging ADC Values Combined with Serum Tumor Markers for Postoperative Recurrence and Metastasis in Patients with Colorectal Cancer
Objectie To study the predictive value of the apparent diffusion coefficient of MR diffusion weighted imaging(ADC)value combined with serum tumor marker carcinoembryonic antigen(CEA),sugar antigen(CA)242 and CA199 for postoperative recurrence and metastasis in patients with colorectal cancer.Methods 120 colorectal cancer patients treated from January 2020 to January 2021 as colorectal cancer group,and 120 healthy patients with colorectal cancer screening as healthy group,were examined by MR diffusion weighted imaging,obtained ADC values,determined the levels of tumor markers such as serum CEA,CA242,CA199,and compared the differences in ADC values,CEA,CA242,CA199 levels and the expression differences in colorectal cancer patients with different clinical characteristics.All patients with colorectal cancer were followed up in outpatient service for 24 months.According to the postoperative follow-up results,they were divided into recurrence and metastasis groups.The clinical data,ADC value,CEA,CA242 and CA199 levels were compared,and the efficacy and correlation of ADC value,CEA,CA 2,CA242 and CA199 to predict postoperative recurrence and metastasis were analyzed.Results TCompared with the healthy group,CEA,CA242 and CA199 levels increased(P＜0.05).The ADC value in patients with stage Ⅲ and low differentiation of colorectal cancer in TNM stage was lower than that in patients with stage Ⅰ/Ⅱ and moderate/high differentiation(P＜0.05).Compared with the group without recurrence,ADC values decreased and CEA,CA242 and CA199 levels increased(P＜0.05).Multivariate Logistic regression analysis showed that postoperative recurrence and metastasis of colorectal cancer patients were influenced by factors such as TNM stage,degree of differentiation,vascular invasion,ADC value,CEA,CA242 and CA199.ROC curve showed that the AUC of ADC,CEA,CA242,CA199 were 0.897,0.800,0.829,0.783,ADC,CA242,CA199;ADC combined with CEA,CA242 and CA199[AUC(95％CI)=0.934,sensitivity and specificity were 90.65％,84.53％,respectively].After analysis of the correlation between ADC values and CEA,CA242 and CA199,there was a significant negative relationship between ADC values and CEA,CA242 and CA199(P＜0.05).Conclusion Magnetic resonance diffusion-weighted imaging ADC values decrease in patients with colorectal cancer and have increased levels of tumor markers,which are related to postoperative recurrence and metastasis in patients,or can be used as an important means to predict postoperative recurrence and metastasis in patients with colorectal cancer.
Magnetic Resonance Diffusion-weighted ImagingApparent Diffusion CoefficientColorectal CancerTumor MarkersPostoperative Recurrence and Metastasis
NETL
NSTL
万方数据
维普
