The Evaluation Value of Magnetic Resonance SWI Sequence Combined with Serum Id1 and IGFBP-3 in Preoperative Grading of Glioma
Objective To analyze the evaluation value of magnetic resonance susceptibility weighting imaging(SWI)sequence combined with serum inhibitor of differentiation 1(Id1)and insulin-like growth factor-binding protein-3(IGFBP-3)in preoperative grading of glioma.Methods A total of 98 glioma patients admitted to our hospital from December 2019 to June 2022 were regarded as the study subjects,according to the worsening situation,they were divided into 46 cases in the low-level group(World Health Organization Level Ⅰ and Ⅱ)and 52 cases in the high-level group(World Health Organization LevelⅢ and Ⅳ);all selected patients underwent magnetic resonance SWI sequence examination;enzyme linked immunosorbent assay(ELISA)was applied to detect serum levels of Id1 and IGFBP-3;Pearson method was applied to analyze the correlation between serum Id1 and IGFBP-3 levels;receiver operating characteristic(ROC)curve was applied to analyze the critical diagnostic points of Id1 and IGFBP-3 levels for preoperative grading of gliomas;four grid table was applied to analyze the diagnostic value of magnetic resonance SWI sequence combined with serum Id1 and IGFBP-3 for preoperative high and low levels of glioma.Results The ITSS grading of the high-level group was obviously higher than that of the low-level group(P＞0.05).The levels of Id1 and IGFBP-3 in the high-level group were obviously higher than those in the low-level group(P＞0.05).According to Pearson correlation analysis,there was a positive correlation between serum Id1 and IGFBP-3 levels in glioma patients(r=0.486,P＜0.05).According to the ROC curve,the area under the curve(AUC)for Id1 and IGFBP-3 in diagnosing preoperative grading of glioma was 0.837 and 0.861,respectively,the AUC of the combination of the two in diagnosing preoperative grading of glioma was 0.908.The accuracy,sensitivity,and specificity of magnetic resonance SWI sequence in preoperative grading diagnosis of gliomas were 83.67％,84.62％,and 82.61％,respectively;the accuracy,sensitivity,and specificity of Id1 in preoperative grading diagnosis of gliomas were 79.59％,80.77％,and 78.26％,respectively;the accuracy,sensitivity,and specificity of IGFBP-3 in preoperative grading diagnosis of gliomas were 81.63％,82.69％,and 80.43％,respectively;the accuracy,sensitivity,and specificity of the combined detection of the three in preoperative grading diagnosis of gliomas were 91.84％,92.31％,and 91.30％,respectively.Condusion Id1 and IGFBP-3 are obviously elevated in the serum of glioma patients.The combination of magnetic resonance SWI sequence and serum Id1 and IGFBP-3 can improve the evaluation value of preoperative grading of glioma.
Magnetic ResonanceSusceptibility Weighting imaginginhibitor Of Differentiation 1Insulin Like Growth Factor-binding Protein-3Glioma
万方数据
维普
