A Resting-state fMRI Study on Patients with Crohn's Disease Based on Fractional Amplitude of Low-frequency Fluctuation and Functional Connectivity
Obyective To investigate changes of brain function in patients with Crohn's disease(CD)in resting state by the fractional amplitude of low-frequency fluctuation(fALFF)combined with functional connectivity(FC).Methods A total of 13 CD patients and 12 healthy controls with their Mini-Mental State Examination(MMSE)scores and Hamilton Depression Scale(HAMD)scores were recruited.All participants underwent resting-state functional MRI scans.The fALFF assessed differences in spontaneous regional brain activity.Differences between the groups were selected as seeds for FC analyses.Correlations between disease clinical data and zfALFF/zFC values in abnormal regions were analyzed.Results Patients with CD had significantly lower zfALFF values in the left inferior parietal marginal angular gyrus,supramarginal gyrus,angular gyrus.They also had higher zfALFF values in the bilateral supplementary motor area,dorsolateral superior frontal gyrus and right precental gyrus.FC strength in the right middle occipital gyrus,middle temporal gyrus was found to be increased when the left supramarginal of inferior parietal was used as the seed point.The zfALFF value in the left left inferior parietal marginal angular gyrus was correlated positively with disease duration as well as the zFC value of the left inferior parietal marginal angular gyrus and right middle occipital gyrus(r=0.555,r=0.623,P＜0.05).The zfALFF value of the right dorsolateral superior frontal gyrus was negatively correlated with the course of disease,the zFC value of the left inferior parietal marginal angular gyrus and the right middle occipital gyrus were negatively correlated with the occurrences of washed microbiota transplantation(WMT)(r=-0.614,r=-0.681,P＜0.05).Conclusion CD patients have functional and regulatory abnormalities in the brain areas responsible for external environmental monitoring,cognitive processing and sensorimotor processing,and WMT has influence on brain network of CD patients.
Crohn's DiseaseResting-state f-MRIFractional Amplitude of Low-frequency FluctuationFunctional Connectivity
万方数据
维普
