Vascular Lesions and Brain Atrophy in Dementia:An Optimized MRI Protocol Reveals Distinctive Radiological Profiles
Objective The study aims to investigate their distribution in patients with Alzheimer's,vascular or mixed dementia and detect any distinctive neuroradiological profiles.Methods Seventy-six subjects received a diagnosis of Alzheimer's(AD=34),vascular(VD=31)and mixed(MD=22)dementia.Three independent raters assessed the brain images acquired with 3T MRI protocol using semiquantitative scales for vascular lesions.Results A greater number of PVL(P=0.002)、[]DWML(P=0.006)、Juxtacortical MB(P=0.007)、Deep MB(P=0.003)was observed in MD compared to AD,while VD showed a significant greater number of DGML(P=0.016)、PVS BG-CS(P=0.005).Comparing VD and MD,No significant difference was observed in Vascular Lesions,but VD showed a higher number of MTA(P＜0.001).No significant difference was observed in scores of cortical atrophy scales and Evans index among the three groups.Conclusion The proposed MRI protocol represents a useful advancement in the diagnostic assessment of patients with cognitive impairment by more accurately detecting vascular lesions,mainly microbleeds,without a significant increase in time and resource expenditure.Our findings confirm that white and grey matter lesions predominate in vascular and mixed dementia,whereas deep and juxtacortical microbleeds predominate in mixed dementia,suggesting that cerebral amyloid angiopathy could be the main underlying pathology.
万方数据
维普
