To Investigate the Diagnostic Value of Multimodal MRI in Adult MELAS Mitochondrial Encephalomyopathy
Objective To explore the diagnostic value of the combined application of multiple functional magnetic resonance imaging in adult mitochondrial encephalomyopathy with lactate and stroke like episodes(MELAS).Methods One MELAS patient,in addition to CT plain scan and routine MRI examination sequences,was supplemented with imaging data from MR angiography(MRA),DWI,MRS,and CASL-PWI.Results The lesions were asymmetrically distributed in a patchy pattern in the brain parenchyma,with a higher incidence in the temporal,parietal,and occipital lobes;MRI T1 sequence has slightly lower signal,T2 sequence has slightly higher signal,FLAIR and DWI signals are higher,and ADC image shows slightly lower signal MRA did not show any abnormal vascular changes in the corresponding area of the lesion;The lesion can simultaneously affect the blood supply areas of both Willis blood vessels MRS showed an increase in lactate peak in the lesion area,and mild elevation of lactate peak was also observed in brain tissue without abnormal signals on MRI plain scan CASL-PWI shows high perfusion in the lesion area.Condusbn Multimodal magnetic resonance imaging is of great value in diagnosing adult MELAS syndrome.
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