Analysis of Functional Changes in Different Brain Regions of Minimal Hepatic Encephalopathy by Resting-state Functional Magnetic Resonance Imaging
Objective To investigate the functional changes of different brain regions in minimal hepatic encephalopathy(MHE)by resting-state functional magnetic resonance imaging(fMRI).Methods A total of 88 patients with liver cirrhosis who were treated in our hospital from February 2017 to May 2022 were selected as the research objects.According to the occurrence of MHE,they were divided into MHE group(n=45)and non-MHE group(n=43),and healthy people who underwent physical examination in our hospital during the same period(n=50)were selected as the control group.The propensity score matching(PSM)method was used to match the three groups according to 1∶1∶1,with 40 cases in each group.The general data of the three groups were compared.All subjects underwent rs-fMRI scan,and the functional connectivity(FC)of different brain regions in the whole brain of the three groups was analyzed and compared by statistical methods.The cognitive function scores of the three groups were analyzed.Spearman correlation test was used to analyze the correlation between cognitive function score and FC changes in patients with cirrhosis.Results Compared with the control group,the FC of bilateral postcentral gyrus,bilateral cuneus/superior occipital lobule,left middle occipital gyrus,left inferior frontal gyrus and right lingual gyrus in MHE group were significantly lower(P＜0.05).Compared with the control group,the NCT-A test results of the MHE group were higher(P＜0.05),and the DST scores were lower(P＜0.05).The scores of NCT-A and DST scales were significantly negatively correlated with FC changes in bilateral cuneus/superior occipital lobule,left inferior frontal gyrus and left superior temporal gyrus(P＜0.05).Conclusion If patients with cirrhosis have MHE,bilateral postcentral gyrus,bilateral cuneus/occipital lobule,left middle occipital gyrus,left opercular inferior frontal gyrus and right lingual gyrus have abnormal FC,cognitive dysfunction will occur.Cognitive dysfunction may be related to FC changes in different brain regions.
Re sting-state Functional Magnetic Resonance imagingMinimal Hepatic EncephalopathyBrain RegionFunctional Connection
万方数据
维普
