摘要
目的 探讨山豆根中毒性脑病患者头颅影像学特点,为临床诊断提供依据.方法 检索万方医学数据库、维普数据库、中国知网、中华医学期刊全文数据库自建库至2023年2月山豆根中毒性脑病文献,提取头颅影像学特点,建立数据并进行分析.结果 研究纳入山豆根中毒性脑病患者87例,学龄前和学龄儿童多见(54/87,62.07％),临床症状表现为头晕、行走不稳、意识障碍、偏身扭转、全身乏力、球麻痹等,头颅影像主要表现:双侧小脑和/或双侧基底节区对称性病变,随中毒剂量增加,累及部位增多(如脑干、脑叶).意识障碍多与双侧基底节区受累有关.头颅MRI表现为:对称性T1低信号、T2高信号,DWI高信号或等信号,ADC低信号或高信号.结论 山豆根中毒性脑病影像学以双侧小脑、双侧基底节区对称性病变为特征,可累及脑干、脑叶,累及部位越多临床症状越重.
Abstract
Objective To investigate the cranial imaging characteristics of patients with toxic encephalopathy caused by Sophora Tonkinensis Gagnep,and to provide a basis for clinical diagnosis.Methods The Wanfang medical database,VIP database,CNKI,Ace Base of CMA were searched from the time of the construction of the libraries to February 2023.The literatures on toxic encephalopathy caused by Sophora Tonkinensis Gagnep were extracted,and the cranial imaging characteristics were established and the data were analyzed.Results 87 patients with toxic encephalopathy were included in the study,most of which were preschooler and school aged children(54/87,62.07％).The main clinical symptoms were vertigo,gait disturbance,co nscious disturbance,torsion spasm,malaise,bulbar paralysis,etc.The main cranial imaging findings were symmetrical lesions in bilateral cerebellum and/or bilateral basal ganglia.With the increase of poisoning dose,the involved sites increased(esuch as brain stem,cerebral hemisphere).Impaired consciousness is frequently associated with bilateral basal ganglia involvement.Cranial MRI scans showed:symmetrical T1 hypointensity,T2 hyperintensity,DWI hyperintensity or isointensity,ADC hypointensity or hyperintensity.Conclusion Imaging of toxic encephalopathy caused by Sophora tonkinensis Gagnep is characterised by symmetrical lesions in the bilateral cerebellum and bilateral basal ganglia that can involve the brainstem and lobes,with the more sites of involvement more clinically severe.
维普
万方数据