Analyze the CT Perfusion Imaging Approaches and Treatment Schemes for Severe Carotid Artery Stenosis Patients
Objective To analyze the computed tomography perfusion imaging(CTP)approaches and treatment schemes for severe carotid artery stenosis patients.Methods 90 severe carotid artery stenosis(CAS)patients treated from June 2020 to June 2021 in our hospital were selected as research subjects.All of patients were confirmed by digital subtraction angiography(DSA)and then examined by CTP.According to the different CTP approaches,patients were divided into unaffected side group,affected side group and basilar group.The cerebral blood volume(CBV),cerebral blood flow(CBF),time to peak(TTP),mean transit time(MTT)and delay time(DT)were compared.According to the perfusion parameters,the asymptomatic patients were chosen and randomly divided into control group(Aspirin and Atorvastatin)and observation group(indobufen tablets and Atorvastatin).Patients were followed for one year.Treatment effects and adverse drug reactions were counted.Results There were no significant differences about CBV and TTP values for severe CAS patients based on three perfusion approaches(P＞0.05);the perfusion parameters between basilar group and unaffected side group were not significantly different(P＞0.05);CBF,MTT and DT values for affected side group were found to be statistically significant with the other two groups(P＜0.05);before therapy,fibrinogen(FIB),D-dimer(D-D),thrombomodulin(TM)and thrombin-activatable fibrinolysis inhibitor(TAFI)levels between observation group and control group showed no statistically significant difference(P＞0.05);after treatment,FIB,D-D,TM and TAFI levels in the observation group were lower than those of control group,with statistically significant difference(P＜0.05);the incidences of adverse reactions like nausea,vomiting,gastrointestinal bleeding and stomachache in the observation group(8.33％)were lower than those of control group(37.50％),with statistically significant difference(P＜0.05);during one-year follow-up visit,the occurrences of adverse events and cerebral stroke in the observation group were lower than those of control group,with statistically significant difference(P＜0.05).Conclusion CTP parameters are less affected by the middle cerebral artery and basilar artery;meanwhile,indobufen tablets can better reduce the occurrences of cerebral stroke and increase the treatment effects and safety for severe carotid artery stenosis patients.
Severe Carotid Artery StenosisCT Perfusion imagingIndobufenAtorvastatinStroke
万方数据
维普
