Clinical Characteristics and CT Findings of Inhibitor Associated Pneumonia at Immuno Checkpoint
Objective To evaluate the value of CT in the diagnosis and treatment of immune checkpoint inhibitor-related pneumonia(CIP).Methods Retrospective analysis of the detailed clinical data and imaging characteristics of 21 CIP patients in our center.Results In 21 patients with CIP,there were 15 males and 6 females.The median time from administration to CIP was 3 months(0.6～13 months),The CT findings were as follows:unilateral lobes were involved in 3 cases,bilateral lobes were involved in 18 cases,symmetrical distribution in 15 cases and asymmetric lung distribution in 5 cases.Imaging classification:10 cases of organic pneumonia,6 cases of non-interstitial pneumonia,4 cases of allergic pneumonia and 2 cases of acute interstitial pneumonia.There was a moderate correlation(r=0.557,P=0.009＜0.05)between clinical grade and imaging grade of 21 cases of CIP.Conclusion The clinical symptoms and CT manifestations of CIP are not typical.CT combined with the history of immunosuppressant treatment at the immunocheckpoint is helpful for early detection and diagnosis of CIP,and provides a basis for determining the treatment plan.
万方数据
维普
