Diagnostic Value of LDCT Combined with Tumor Markers in Early Stage Lung Cancer among High-risk Population
Objective To evaluate the diagnostic efficacy of low-dose spiral computed tomography(LDCT)combined with six tumor markers(CYFRA21-1,SCC,NSE,GRP,CEA,CA 125)for early stage lung cancer in high-risk population.Methods The data of subjects with successful follow-up and pathological results and subjects with negative CT results from 2015 to 2019 were statistically analyzed.The levels of CT and serum tumor markers and the diagnostic value of combined detection of CT signs and serum tumor markers for lung cancer were compared and analyzed.Results The sensitivity and specificity of CT were 81.48％and 50.00％respectively.The sensitivity and specificity of tumor markers were 66.67％and 66.67％respectively.The sensitivity of CT combined with tumor markers was 62.96％,and the specificity was 100.00％.The tumor markers level in lung cancer group were significantly higher than those in LDCT negative subjects,while the TM test results of CT negative subjects were all negative,there was statistical significance between the two groups(P＜0.05).Conclusion LDCT has higher sensitivity and lower specificity,while the specificity of tumor markers is the highest.The combination of LDCT and tumor markers of lung cancer can complement each other and have great value in the early detection of lung cancer.This will improve the false positive rate and over-diagnosis of LDCT lung cancer screening,and can be used as a first-line auxiliary screening method.TM test is not recommended for subjects with negative CT results.
万方数据
维普
