Clinical Study of Serum NSE,CYFRA21-1 Combined with CT Imaging to Distinguish Benign and Malignant Pulmonary Nodules
Objective To investigate the clinical application value of serum tumor markers neuron specific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1)and computed tomography(CT)in the diagnosis of benign and malignant pulmonary nodules.Methods A retrospective study was conducted on 396 patients with pulmonary nodules confirmed by pathological examination in our hospital from June 2020 to June 2021.CT imaging features and serum tumor markers NSE and CYFRA21-1 were compared between the benign and malignant pulmonary nodules.The clinical performance of serum NSE,CYFRA21-1 and CT imaging in distinguishing benign and malignant pulmonary nodules were analyzed.Results The incidence of ground glass or mixed ground glass nodule,foliation sign and burr sign in the CT signs of malignant pulmonary nodules was significantly higher than that of benign nodules,and the nodules were larger in diameter.Serum tumor markers NSE and CYFRA21-1 levels were significantly increased in patients with pulmonary malignant nodules(P＜0.05).The sensitivity and specificity of NSE and CYFRA21-1 combined with CT imaging were 78.60％and 83.43％,which were significantly higher than tumor markers.Conclusion Serum NSE and CYFRA21-1 combined with CT have higher clinical performance in the diagnosis of benign and malignant pulmonary nodules.
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