Prognostic Study of CT Detection of Emphysema in Small Cell Lung Cancer Patients
Objective The aim of this study is to analyze the prognostic value of emphysema scores in small cell lung cancer(SCLC)patients determined by baseline CT scans,in order to provide reference for clinical diagnosis and treatment.Methods Clinical data of 149 patients with small cell lung cancer were analyzed.Use the Goddard scoring system to semi quantitatively score the severity of emphysema on baseline chest CT images,and collect data on clinical features and survival rates.Survival estimation was conducted using the Kaplan Meier method,and comparison was conducted using the logarithmic rank test.Use a multivariate Cox proportional risk model to determine prognostic factors.Results The median CT emphysema score of 149 patients was 4 points(0-23 points).During a median follow-up of 29.0 months[95％confidence interval:19.7-38.3 months],123 patients(82.6％)died.The median OS of all study subjects was 9.6 months(95％confidence interval:7.2-11.9 months).Multivariate analysis showed that a higher CT emphysema score[HR,1.85;95％CI,1.14-3.00;P=0.012],extensive staging(HR,2.27;95％CI,1.45-3.53;P＜0.001),elevated lactate dehydrogenase(HR,1.52;95％CI,1.03-2.23;P=0.034),and only supportive treatment(HR,6.46;95％confidence interval,3.64-11.48;P＜0.001)were significant independent prognostic factors for poor prognosis.Conclusion The severity of emphysema determined by baseline CT is significantly correlated with the adverse prognosis of small cell lung cancer.
万方数据
维普
