Objective To explore the clinical value of multi-modal MRI combined with carbohydrate antigen(CA)125,CA153 and CA199 in predicting postoperative recurrence and metastasis of breast cancer.Methods Analyzed the clinical data of486 patients who underwent radical mastectomy in our hospital from June 2018 to June 2021.They were divided into recurrence and metastasis group(65 cases)and in non-recurrence and metastasis group(421 cases)according to postoperative recurrence and metastasis.The related parameters of multi-modal MRI[transfer constant(Ktrans),rate constant(Kep),apparent diffusion coefficient(ADC)]and serum CA125,CA153 and CA199 levels were compared between the two groups.ROC curve was used to analyze the predictive value of multi-modal MRI combined with serum tumor marker detection on recurrence and metastasis after breast cancer surgery.Results There were statistically significant differences in menopause status,tumor diameter and tumor staging in recurrence and metastasis group compared with those in non-recurrence and metastasis group(P＜0.05).Ktrans and Kep in recurrence and metastasis group were higher than those in non-recurrence and metastasis group(P＜0.05)while ADC value was lower than that in non-recurrence and metastasis group(P＜0.05).The levels of serum CEA,CA125 and CA153 were higher in recurrence and metastasis group than those in non-recurrence and metastasis group(P＜0.05).ROC results showed that the AUCs of Ktrans,Kep,ADC value,serum CA125,CA153 and CA199 in the diagnosis of recurrence and metastasis after breast cancer surgery were 0.768,0.852,0.735,0.914,0.927 and 0.859 respectively(P＜0.05).The AUC of combined diagnosis was 0.978(P＜0.05).Conclusion Multi-modal MRI combined with CA125,CA153 and CA199 has a good predictive value on recurrence and metastasis after breast cancer surgery.
关键词
乳腺癌术后/复发转移/多模式MRI/糖类抗原125/糖类抗原153/糖类抗原199
Key words
After Breast Cancer Surgery/Recurrence and Metastasis/Multi-modal MRI/Carbohydrate Antigen 125/Carbohydrate Antigen 153/Carbohydrate Antigen 199
维普
万方数据