Value of Contrast-enhanced Ultrasound and DCE-MRI in Evaluating Neoadjuvant Chemotherapy of Breast Cancer Patients
Objective To investigate the value of contrast-enhanced ultrasound(CEUS)and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in evaluating neoadjuvant chemotherapy(NAC)of breast cancer patients.Methods A total of 68 breast cancer patients who underwent NAC in the hospital from January 2020 to January 2023 were selected.All patients enrolled were examined with CEUS and DCE-MRI after NAC.With surgical and pathological results as the golden standard,the patients were divided into effective group and ineffective group.The value of CEUS,DCE-MRI,and their combination in evaluating the efficacy of NAC in breast cancer patients was compared.CEUS parameters and DCE-MRI parameters were compared between the effective group and the ineffective group.Results Surgical and pathological results showed that there were 49 cases in the effective group and 19 cases in the ineffective group.The sensitivity,specificity and accuracy of CEUS for evaluating the efficacy of NAC were 81.63％,68.42％and 67.65％.The peak intensity(PI)and the area under the curve(AUC)of effective group were lower than those of ineffective group(P＜0.05).The sensitivity,specificity and accuracy of DCE-MRI were 83.67％,73.68％and 67.65％.The volume transfer constant(Ktrans)and rate constant(Kep)of effective group were lower than those of ineffective group(P＜0.05).The sensitivity and accuracy of CEUS combined with DCE-MRI for evaluating the efficacy of NAC were 97.96％and 94.83％,significantly higher than those of single evaluation(P＜0.05).Conclusion CEUS combined with DCE-MRI can improve efficacy evaluation of NAC in patients with breast cancer,with high sensitivity and accuracy.
Contrast-enhanced UltrasoundDynamic Contrast-Enhanced Magnetic Resonance imagingBreast CancerNeoadjuvant ChemotherapyEvaluation Value
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