Relationship between MRI Parameters and Tumor Histological Grading and Microvascular Infiltration in Hepatocellular Carcinoma Patients
Objective To investigate the relationship between MRI enhanced scanning parameters and tumor histological grading and microvascular invasion(MVI)in patients with hepatocellular carcinoma(HCC).Methods Clinical data of 181 patients who underwent enhanced MRI scans from January 2019 to December 2022 were retrospectively collected.They were divided into the low-grade tumors(GradeⅠ,Ⅱ)and the high-grade tumors(Grade Ⅲ and Ⅳ)based on Edmondson-Steiner Grading.And also were divide into the MVI positive group and the MVI negative group based on the occurrence of MVI.Multivariate logistic regression model were used to analyze independent risk factors of MVI and high-grade histological differentiation.Results There were 118 cases in the MVI positive group and 163 cases in the MVI negative group,as well as 51 cases in the low-grade group and 130 cases in the high-grade group.The AFP levels were statistically significant in the MVI positive and the MVI negative groups,as well as in the low-grade and high-grade groups(P=0.002 and 0.041).The proportion of patients with liver cirrhosis in the high-grade group is relatively low(P=0.015).The results of multivariate logistic regression showed that the presence of multiple tumors(OR=4.252,P=0.000),tumor diameter ≥ 5cm(OR=5.167,P=0.000),arterial phase peritumoral enhancement(OR=5.156,P=0.000),and low signal intensity(OR=4.163,P=0.000)were independent risk factors for MVI in HCC patients,while intact capsule(OR=0.295,P=0.000)was a protective factor for MVI.Liver cirrhosis(OR=0.873,P=0.000)with intact capsule(OR=0.283,P=0.000)is a protective factor,while multiple tumors(OR=5.116,P=0.000)with lobulated tumor shape(OR=5.276,P=0.000)are independent risk factors for high-grade histopathological changes in HCC patients.Conclusion There is a certain correlation between preoperative enhanced MRI imaging parameters and MVI and histological differentiation in HCC patients,and its predictive value is worth further research.
万方数据
维普
