A Preliminary Study of Personalized Contrast Agent in the Liver with CT Scanning
Objective evaluate the image quality and its repeatability of contrast agent personalization in liver enhanced CT applications.Methods A total of 192 consecutive patients whom suspected liver disease were recruited and accepted tri-phase enhanced CT scans with a personalized Iodine contrast medium protocol prospectively,using a 64-MDCT scanner.Recording the actual unit weight iodine dose,effective total iodine dose,real injection rate.The image quality and the reproducibility was evaluated,and physician consistency was tested by Kappa coefficient or paired data MaNemar.Results A total of 192 subjects were included,of whom 109 males and 83 females,the actual unit weight iodine dose was(374.8±52.1)mgl/Kg,actual injection iodine flow rate was(1138.0±130.9)mgl/s,effective total iodine dose was(21320.0±3017.7)mgl.The measurement showed that the enhancement unit(EU)of hepatic parenchymal phase is(53.2±7.0)Hu.The evaluation showed that the proportion of aortic enhancement meeting the diagnosis was about 89.06％during arterial phase;the proportion of the scanning timing meeting the diagnosis was about 94.3％during the arterial phase timing;the proportion of liver EU meeting the diagnosis was about 97.9％during hepatic parenchymal phase.There was no significant difference in the evaluation of inter physician aortic enhancement(x2=3.333),scanning timing(x2=1.833),and hepatic parenchymal enhancement effect(x2=7.667)(P≥0.05).The image evaluation of two physicians were highly consistent(kappa values were 0.861,0.803,0.914,P=0.000),and there was no statistical difference between the single sample mean and 50Hu(t=1.745,P=0.083),the coefficient valiance meet 13.13％.Of them,16 subjects underwent initial and follow-up scans,with liver parenchymal EU values of(49.8±6.4)Hu and(50.3±6.7)Hu,respectively,and there was no significant statistical difference between the mean difference(-0.5000±2.8432)and zero(t=-0.703,P=0.493).Conclusion The personalized contrast agent scheme obtained not only a well-quality image in liver,but the good repeatability.This technology is easy to operable,and has high clinical promotion value.
万方数据
维普
