Value of CT-guided 125I Seed Implantation Combined with TACE+Radiofrequency Ablation in the Treatment of Subcapsular Small Liver Cancer
Objective To explore the value of computed tomography(CT)-guided radioactive 1251 seed implantation combined with transcatheter arterial chemoembolization(TACE)+radiofrequency ablation in the treatment of subcapsular small liver cancer.Methods A total of 80 patients with subcapsular small liver cancer were enrolled as the research objects between January 2020 and February 2022.They were randomly divided into observation group and control group,40 cases in each group.The control group was treated with TACE+radiofrequency ablation,while observation group was additionally treated with CT-guided 125 I seed implantation.The objective remission rate(ORR),liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil)],serum tumor markers[alpha-fetoprotein(APF),carcinoembryonic antigen(CEA)],adverse reactions and progression-free survival(PFS)were compared between the two groups.Results The ORR in observation group was higher than that in control group(85.00％vs 62.50％,x2=5.230,P＜0.05).There was no significant difference in ALT,AST or TBil between the two groups(P＞0.05).After treatment,APF and CEA in observation group were lower than those in control group(t=7.616;t=8.938,P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).The 1-year progression-free survival rate in observation group was higher than that in control group(80.00％vs 50.00％,Log Rank x2=7.487,P＜0.05).Conclusion The curative effect of CT-guided 125I seed implantation combined with TACE+radiofrequency ablation is significant on subcapsular small liver cancer,which can effectively reduce levels of serum tumor markers and improve progression-free survival rate,with good safety.
Small Liver CancerRadioactive 1251 SeedTranscatheter Arterial ChemoembolizationRadiofrequency Ablation
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