Predictive Analysis of IVIM Quantitative Parameters Combined with Serum Visfatin Levels for Postoperative Recurrence/Metastasis of Prostate Cancer after Radical Surgery
Objective To analyze the predictive value of intravoxel incoherent motion imaging(IVIM)quantitative parameters combined with serum visfatin levels for postoperative recurrence/metastasis of prostate cancer after radical surgery.Methods A total of 100 patients who underwent radical prostatectomy at the Second Affiliated Hospital of Hunan University of Chinese Medicine from April 2015 to October 2021 were included as the study subjects.All patients were followed up for 18 months after discharge,and the recurrence/metastasis status of the patients during the follow-up period was analyzed and divided into an occurrence group(39 cases)and a non occurrence group(61 cases).The IVIM quantitative parameters of prostate tissue[true diffusion coefficient(D),pseudo diffusion coefficient(D*),perfusion fraction(f)],serum visfatin level and other baseline data were compared between the two groups.The influencing factors of recurrence/metastasis after radical prostatectomy was explored,and the predictive value of IVIM quantitative parameters combined with serum visfatin level for recurrence/metastasis after radical prostatectomy was evaluted.Results The Gleason score and PSA level at admission in the occurrence group were higher than those in the non occurrence group,with a statistical significant difference(P＜0.05).The D and D*values in the occurrence group were lower than those in the non occurrence group,while the f and visfatin levels were higher than those in the non occurrence group,with statistical significant differences(P＜0.05).The results of multivariate Logistic regression analysis showed that high levels of D,D*,f,and visfatin were the influencing factors for postoperative recurrence/metastasis of prostate cancer after radical surgery(P＜0.05).The ROC curve showed that the quantitative parameters of IVIM(D,D*,f)and serum visfatin had certain predictive value for postoperative recurrence/metastasis of prostate cancer(AUC＞0.7).However,the AUC of the combined prediction of recurrence/metastasis was the largest.Conclusion The combination of quantitative parameters of IVIM and serum visfatin levels can effectively predict the risk of recurrence/metastasis after radical prostatectomy,providing a theoretical reference for clinical treatment.
万方数据
维普
