The Value of MRI Combined with Serum MMP-9 and AFP in Prenatal Diagnosis of Dangerous Placenta Previa
Objective To analyze the value of magnetic resonance imaging(MRI)combined with serum matrix metalloproteinase-9(MMP-9)and alpha-fetoprotein(AFP)in prenatal diagnosis of dangerous placenta previa(PPP).Methods A total of 206 suspected PPP patients admitted to our hospital from January 2017 to January 2022 were selected,124 patients with PPP were identified as PPP group by pathological examination after parturition,including 62 patients in placental implantation group and 62 patients in placental non-implantation group.60 healthy pregnant women without placenta previa admitted to our hospital were regarded as the control group;the serum levels of MMP-9 and AFP were detected by enzyme-linked immunosorbent assay(ELISA);the value of serum MMP-9 and AFP in the prenatal diagnosis of PPP patients was analyzed by the ROC curve;the diagnostic efficacy of MRI combined with serum MMP-9 and AFP detection for PPP was analyzed with a four-grid table.Results Compared with the control group,the serum levels of MMP-9 and AFP in the PPP group were obviously higher(P＜0.05).Compared with the control group,the serum levels of MMP-9 and AFP in the placental implantation group and the placental non-implantation group were obviously higher;the levels of MMP-9 and AFP in placental implantation group were obviously higher than those in placental non-implantation group(P＜0.05).there were obvious differences among the three groups in the number of mixed signals in the placenta,unclear demarcation between the placenta and the myometrium,extrauterine process,low T2WI signal,multiple blood vessels in the placenta,thick and bladder processes(P＜0.05).Compared with the control group,the placental thickness of the placental implantation group and the placental non-implantation group increased obviously;the placental thickness of the placental implantation group was obviously higher than that of the placental non-implantation group(P＜0.05).The area under the curve of MMP-9 combined AFP in the diagnosis of PPP was obviously higher than that of MMP-9 and AFP alone diagnosis(P＜0.05).MRI combined with serum MMP-9 and AFP had the highest sensitivity and accuracy in diagnosing PPP(P＜0.05).Condusion MRI combined with serum MMP-9 and AFP can improve the diagnostic value of PPP.
Magnetic Resonance ImagingMatrix Metalloproteinase-9Alpha-fetoproteinPernicious Placenta Previa
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