The Application Value of DCE-MRI Combined with ADC,CA125,HE4 in Differentiating Benign and Malignant Ovarian Epithelial Tumors
Objective To investigate the differential diagnostic efficacy of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI),apparent diffusion coefficient(ADC),serum carbohydrate antigen 125(CA125),human epididymal secreted protein(HE4),and their combined applications in benign and malignant ovarian epithelial tumors,and to explore the best method for the diagnosis of ovarian epithelial tumors.Methods A retrospective analysis was conducted on 76 patients with ovarian epithelial tumors admitted to our hospital from January 2022 to December 2022,with 36 cases confirmed to be benign and 40 cases confirmed to be malignant by pathology.Record the quantitative parameters Ktrans of DCE-MRI in patients with benign and malignant tumors,and draw ROI(area of interest)on the ADC map automatically generated by DWI scanning to obtain ADC values,and retrieve its CA125 and HE4 indicators through the LIS system and perform statistics,at the same time,pathological diagnosis results are used as the gold standard,Calculate the sensitivity and specificity of different examination methods and their combined applications in diagnosing benign and malignant ovarian epithelial tumors.Results The diagnostic sensitivity of Ktrans,ADC,CA125,and HE4 indicators for benign and malignant ovarian epithelial tumors was 92.5％,80.0％and 72.5％respectively,with specificity of 86.1％,75.0％and 88.8％;The levels of CA125 and HE4 in the malignant group were significantly higher than those in the benign group;The sensitivity and specificity of combined application for benign and malignant ovarian epithelial tumors were higher than those of single examination,with statistical differences(P＜0.05).Conclusion The efficacy of DCE-MRI combined with ADC,CA125,and HE4 in the differential diagnosis of benign and malignant ovarian epithelial tumors is superior to that of a single examination,which can improve the value of preoperative differential diagnosis of benign and malignant ovarian epithelial tumors.
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