Value of Dual-energy CT Combined with Clinicopathological Characteristics in Predicting the Expression of Ki-67 in Colorectal Cancer
Objective To investigate the value of dual-energy CT(DECT)combined with clinicopathological characteristics in predicting the positive expression of proliferating antigen Ki-67 in colorectal cancer(CRC).Methods 123 adenocarcinoma CRC patients proved by pathological examination were postoperatively analysed.All patients underwent baseline abdominal and/or pelvic contrast enhanced dual-energy CT(DECT)scan in our institution.All patients were divided into high expression and low expression group according to the expression of Ki-67,The iodine concentration(IC),normalized iodine concentration(NIC)and slope of energy spectrum curve(λHU)were measured by DECT analysis workstation.Chisquare was used to compare the clinical data and the t/Mann-Whitney U test were used to compare energy spectrum parameters between the two groups.The parameters with statistical significance were analyzed by receiver operating characteristic curve(ROC),and the prediction efficiency of the parameters was evaluated.Results There was significant difference in the serum CA199 levels(x2=5.559,P＜0.05).The biphasic IC,NIC and the slope of energy spectrum curve in Ki-67 high expression group were significantly higher than those in Ki-67 low expression group.Conclusion DECT quantitative parameters IC,NIC,λHU and serum CA199 can reflect the proliferation degree of colorectal cancer cells to some extent and predict the positive expression level of Ki-67 in colorectal cancer.
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