The Application Value of Skeletal Muscle MRI Imaging in Duchenne Muscular Dystrophy
Objective To analyze the clinical application value of skeletal muscle magnetic resonance imaging(MRI)imaging technology in Duchenne muscular dystrophy(DMD).Methods Clinical data of 64 DMD patients admitted to our hospital from May 2019 to May 2022(DMD group)were collected.Additionally,16 healthy boys who had no history of neuromuscular disorders or muscle weakness in our hospital were selected for MRI skeletal muscle imaging examination(control group).All the subjects underwent T1WI muscle Coronal plane scan,transverse T1WI and T2WI-STIR fat suppression sequence examination,observed the MRI images,analyzed the characteristics of muscle fat infiltration and edema,compared the differences of MRI fat infiltration and edema cumulative scores in different populations and patients with different clinical characteristics,and analyzed the correlation between MRI fat infiltration,edema cumulative scores and patients'clinical characteristics.Results The degeneration of the affected muscles in the T1WI and T2WI-STIR fat examinations of DMD patients was high signal,indicating that normal muscle tissue was replaced by infiltration of adipose tissue;The MRI examination of the control group showed moderate intensity signals.The thigh muscles of 64 DMD patients showed different degrees of fat infiltration,with Gluteus maximus being the most affected(100％)and gracilis being the least affected(39.06％);The score of fat infiltration on T1WI was 4,the highest was Gluteus maximus(62.50％),the lowest was Sartorius muscle muscle and gracilis muscle;The proportion of patients whose T1WI fat infiltration score was 0 was the highest in gracilis muscle(60.94％),followed by Sartorius muscle(56.25％).In 51 patients,the thigh muscles showed edema changes of varying degrees,and the frequency of involvement was lower than that of fat infiltration,which showed a bilateral asymmetric distribution.The Biceps femoris muscle was most affected(64.06％),and the tensor fasciae latae muscle was least affected(20.31％);The highest T2WI-STIR edema grade of 3 was semitendinosus(17.19％),and the highest grade of 0 was Tensor fasciae latae muscle(79.69％).The cumulative scores of MRI fat infiltration and edema in the DMD group were significantly higher than those in the control group(P＜0.05).There were differences in MRI fat infiltration scores among DMD patients with different age,height,weight,and clinical motor function grading(P＜0.05),Pearson correlation results showed a positive correlation between MRI fat infiltration and patient age,height,weight,and clinical motor function(P＜0.05),but no correlation with BMI(P＞0.05);There was no correlation between edema score and various clinical characteristics of DMD patients(P＞0.05).Conclusion MRI imaging of skeletal muscles in DMD patients has certain characteristics,and the MRI fat infiltration score can reflect the degree and severity of muscle involvement,which is closely related to the patient's clinical motor function,and has reference value for clinical diagnosis and treatment and disease severity assessment.
万方数据
维普
