The Value of Multimodal MRI Functional Imaging in the Assessment of Postoperative Recurrence and Posttreatment Response in Gliomas of the Brain
Objective To compare the diagnostic value of MR diffusion-weighted imaging(DWI)and three-dimensional arterial spin labeling imaging(3D ASL)in identifying postoperative recurrence of gliomas and post-treatment response,and to provide an objective basis for precise clinical treatment.Methods We retrospectively analyzed 47 cases who underwent glioma surgery,postoperative radiotherapy for more than 1 month,and the first appearance of abnormal enhancing lesions during follow-up during January 2019---July 2023 in our hospital,and the patients underwent conventional MRI plain and enhanced scans,DWI,and 3D ASL,and measured the apparent diffusion coefficient(ADC)value and relative ADC(rADC)value of DWI,and the hemodynamic parameter CBF of 3D ASL,respectively.ASL hemodynamic parameters CBF values and relative CBF(rCBF)values.The diagnostic efficacy of each parameter in discriminating postoperative recurrence from post-treatment response was analyzed using two-sample t-tests,and subject working characteristic curves(ROC).Results The 47 patients,30 had glioma recurrence and 17 had post-treatment response.1.The CBF value of the enhanced zone of glioma recurrence was(119.16±18.58)mL/100g/1min,and that of the post-treatment response zone was(72.06±22.77)mL/100g/1min,with a statistically significant difference(P＜0.05);the cerebral The rCBF value in the enhanced area of glioma recurrence was 3.56±1.13,and the rCBF value in the area of radiation damage was 1.18±0.39,and the difference was statistically significant(P＜0.05);2.There was no significant difference in ADC between glioma recurrence and post-treatment response(P=0.235);the difference in rADC(P＜0.05)between glioma recurrence and post-treatment response was statistically significant;3.3D ASL(rCBF)diagnosed glioma recurrence with an area under the curve of approximately 0.971 and ADC diagnosed glioma recurrence with an area under the curve of approximately 0.675.Conclusion 3D ASL imaging showed better diagnostic efficacy in identifying glioma recurrence and post-treatment response compared to DWI sequences.
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