Construction of Hyperbilirubinemia Neonatal Model Based on Globus Pallidus/Putamen T1WI Signal Intensity Ratio and Its Predictive Value for Bilirubin Encephalopathy
Objective To explore the factors influencing the globus pallidus/putamen(G/P)T1WI signal intensity ratio in neonates with hyperbilirubinemia(HB)and to build a model for predicting the risk of acute bilirubin encephalopathy(ABE).Methods A retrospective analysis was performed on 140 cases of HB neonates and 3 cases of ABE neonates who received cranial MR examination in our hospital from July 2017 to December 2022.Clinical data were collected for both groups including sex,age,gestational age,birth weight,Serum total bilirubin(TB),serum total bilirubin/albumin(B/A)ratio,the presence or absence of neonatal infection or sepsis,ABO hemolysis,glucose-6-phosphate dehydrogenase(G6PD)deficiency,and acidosis.A Logistic regression model was constructed to screen out the influencing factors of G/P ratio in HB neonatal,and to explore whether multiple regression equation based on G/P ratio of HB neonatal could predict the risk of BE.Results Age[OR=0.747(95％CI 0.674-0.828)],gestational age[OR=0.942(95％CI 0.905-0.981)]and serum total bilirubin[OR=1.004(95％CI 1.000-1.008)]were the influencing factors of G/P ratio in HB neonatal.The multiple linear regression equation was of HB neonatal was Y(predicted G/P)=2.945-0.018x×X1(age)-0.004×X2(gestational age)+0.0003×X3(total serum bilirubin).When measurement value of G/P ratio is 8％higher than that of predicted value,attention should be paid to the risk of ABE.Conclusion Age,gestational age and serum total bilirubin are the factors influencing the G/P ratio of HB neonates,and the multiple linear regression model based on the G/P ratio of HB neonates can predict the risk of ABE.
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