Clinical Application of D-CBCT in Precise Treatment of Lung Cancer by Volumetric Modulated Arc Therapy Program
Objective The aim of this study was to investigate the clinical application of cone-beam CT(D-CBCT)in the precise treatment of lung cancer by volumetric modulated arc therapy(VMAT)program.Methods A total of 100 patients with lung cancer treated in Radiotherapy Department of Nantong Third People's Hospital were enrolled and divided into 4D group(n=57)and 3D group(n=43)according to CBCT scan modes between October 2019 and October 2022.The radiotherapy setup errors,internal target volume(ITV)volume,target dose,cardiac exposure dose and tumor control effect in the two groups were compared.Results Before and after correction and after treatment,the difference in absolute values of setup errors between the two groups was not statistically significant(P＞0.05).ITV volume of middle and inferior lobe tumors in 4D group was smaller than that in 3D group(P＜0.05),maximum dose(Dmax),minimum dose(Dmin)and mean dose(Dmean)were higher than those in 3D group(P＜0.05),V10,V20,V30 and mean exposure dose(Dmean)were lower than those in 3D group(P＜0.05).There was no significant difference in objective response rate between the two groups(P＞0.05).Conclusion The application of D-CBCT,especially 4D-CBCT in precise treatment of lung cancer by VMAT program can better provide target dose,reduce ITV volume of middle and inferior lobes and cardiac exposure dose.
万方数据
维普
