Objective To investigate the qualitative value of low-dose CT(LDCT)+peripheral blood thymidine kinase 1(TK1)on pulmonary nodules,and to construct a diagnostic model of malignant pulmonary nodules and test it.Methods Two hundred and forty-four patients with pulmonary nodules admitted to our hospital from February 2020 to January 2023 were selected,and both LDCT and conventional-dose CT scans of the lungs were performed to compare the image quality,radiation dose,and imaging characteristics of LDCT and conventional-dose CT.The patients were divided into malignant group(n=105)and benign group(n=139)according to the pathological diagnosis,and the LDCT examination results and peripheral blood TK1 were compared between the two groups,and the influencing factors of malignant pulmonary nodules were analyzed by logistic regression,and the column line graph diagnostic model was constructed using R language and evaluated and validated.ResultsThe image noise values at the level of the superior edge of the diaphragm,the level of the bronchial bifurcation,and the level of the superior edge of the aortic arch at LDCT were higher than those at conventional dose CT,and the radiation dose ED,DLP,and CTDIvol were lower than those at conventional dose CT(P＜0.05);the proportion of patients with pleural depression sign,bronchial sign,vascular sign,lobar sign,burr sign,and irregular morphology was higher in the malignant group than in the benign group,and the peripheral blood TK1 level was higher than that in the benign group(P＜0.05).Logistic regression analysis showed that pleural depression sign,bronchial sign,vascular sign,lobar sign,burr sign,morphological irregularity,and TK1 were associated with malignant pulmonary nodules(P＜0.05);the diagnostic model of malignant pulmonary nodules was plotted in R language with a C-index of 0.907,and ROC analysis showed that the constructed diagnostic model was higher than any of the individual variables,suggesting that the diagnostic model has The calibration curve analysis showed that the constructed diagnostic model was in good agreement with the actual observation results.Conclusion Local LDCT features of pulmonary nodules(pleural depression sign,bronchial sign,vascular sign,lobar sign,burr sign,morphological irregularity)and TK1 are closely related to malignant pulmonary nodules,and the diagnostic model of malignant pulmonary nodules constructed based on the above factors has good predictive efficacy and reliability,which can provide reference for clinical screening of malignant pulmonary nodules.
LDCTPeripheral BloodTK1Pulmonary NodulesDiagnostic Model
万方数据
维普
