Application of DCE-MRI Combined with DWI Scan in the Diagnosis of Breast Cancer and Curative Effect Evaluation of Neoadjuvant Chemotherapy
Objective To analyze the application of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with diffusion-weighted imaging(DWI)scan in the diagnosis of breast cancer and curative effect evaluation of neoadjuvant chemotherapy.Methods A total of 80 patients with breast tumor admitted to the hospital were enrolled as the observation objects between February 2019 and February 2023.All underwent DWI and DCE-MRI scans before and after surgery.The results of operation and pathology were taken as the gold standard,and the consistency of DWI,DCE-MRI and Kappa between combined examination and pathology were analyzed.The tumor apparent diffusion coefficient(ADC),before and after treatment,left and right,upper and lower diameter,tumor volume and the type of time-signal intensity curve(TIC)curve of breast cancer patients before and after chemotherapy were compared.Results In the 80 patients with breast tumor,pathological examination showed that there were 16 cases with malignant tumors and 64 cases with benign tumors.According to the results of operation and pathology as the gold standard,the sensitivity and specificity of DWI for benign and malignant breast were 87.50％and 71.88％,respectively,and the Kappa value was 0.432.The sensitivity and specificity of DCE-MR in detecting benign and malignant breast were 81.25％and 75.00％respectively,and the Kappa value was 0.431.The sensitivity and specificity of DWI+DCE-MRI combined with benign and malignant breast were 93.75％and 71.88％respectively,and the Kappa value was 0.469.After chemotherapy,front-back,left-right and upper-lower diameters and tumor volume were significantly decreased(P＜0.05).Before and after chemotherapy,there was no significant difference in ADC(P＞0.05),but there were significant differences in number of type Ⅰ,type Ⅱ and type Ⅲ TIC curves(P＜0.05).Conclusion DCE-MRI combined with DWI can effectively diagnose benign and malignant breast tumors,which can accurately reflect the changes of histomorphology and TIC curves after neoadjuvant chemotherapy.
Breast CancerNeoadjuvant ChemotherapyDiffusion-weighted ImagingDynamic Contrast-enhanced MRI
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