Application of DCE-MRI Quantitative Parameters in Evaluating Staging and Prognosis of Breast Cancer
Objective To observe the application of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative parameters in evaluating staging and prognosis of breast cancer.Methods A total of 94 female patients with breast cancer and 92 female patients with benign breast lesions in the hospital were enrolled as breast cancer group and benign lesion group between January 2019 and January 2020.All underwent DCE-MRI quantitative parameters detection before surgery.The volume transfer constant(Ktrans),reflux rate constant(Kep)and extracellular-extravascular volume fraction(Ve)in the two groups were compared,and differences of the above indexes in patients with different staging and prognosis were analyzed.The diagnostic efficiency of quantitative parameters for prognosis of breast cancer was analyzed by ROC curves.Results Ktrans and Kep in patients with breast cancer were greater than those with breast benign hyperplasia,while Ve was lower than that with breast benign hyperplasia(P＜0.05).There were significant differences in Ktrans,Kep and Ve among patients with different breast cancer staging(P＜0.05).With the progression of the disease,Ktrans and Kep were increased,while Ve was decreased.Pearson correlation analysis showed that preoperative staging of breast cancer was positively correlated with Ktrans and Kep,while negatively correlated with Ve(P＜0.05).Ktrans and Kep in poor prognosis group were greater than those in good prognosis group(P＜0.05).The results of ROC curves analysis showed that AUC and specificity of Ktrans were the highest for predicting poor prognosis of breast cancer.Conclusion DCE-MRI quantitative parameters(Ktrans,Kep,Ve)are closely related to clinical staging of breast cancer,which can be applied to evaluate prognosis of breast cancer.
DCE-MRI Quantitative ParameterStaging Of Breast CancerPrognosis Evaluation
万方数据
维普
