Clinical Value of MRI Combined with Serum CENPU and HSP90α in the Diagnosis of Breast Cancer
Objective To study the clinical value of magnetic resonance imaging(MRI)combined with serum centromere protein U(CENPU)and heat shock protein 90α(HSP90α)in the diagnosis of breast cancer.Methods A total of 227 patients with suspected breast cancer who were hospitalized in our hospital from January 2021 to April 2023 were included for study,and 227 patients with suspected breast cancer were separated into 143 cases of breast cancer group and 84 cases of benign tumor group according to the results of postoperative pathological diagnosis as the gold standard.MRI examinations were performed on all patients,enzyme-linked immunosorbent assay was applied to detect serum HSP90α level,qRT-PCR method was applied to detect serum CENPU level.Receiver operating characteristic was applied to analyze the diagnostic value of serum CENPU and HSP90α levels for breast cancer,the four Tabula recta method was applied to analyze the diagnostic value of MRI and its combination with serum CENPU and HSP90αlevels in breast cancer.Results The levels of serum CENPU and HSP90α in breast cancer group were obviously higher than those in benign tumor group(P＜0.05).The AUC of serum CENPU level in diagnosis of breast cancer was 0.739,the sensitivity was 65.73％,and the specificity was 76.19％;the AUC of HSP90α level in diagnosis of breast cancer was 0.767,the sensitivity was 79.72％,and the specificity was 64.29％.MRI showed that 137 patients with breast cancer and 90 patients with benign tumor;50 cases of invasive ductal carcinoma,47 cases of breast ductal carcinoma in situ,27 cases of papilloma,and 13 cases of invasive lobular carcinoma were detected.The sensitivity,specificity and accuracy of MRI in breast cancer were 76.92％,67.86％and 73.57％respectively;the diagnosis result of MRI for breast cancer was consistent with that of pathology(Kappa value=0.441,P＜0.05).The sensitivity,specificity and accuracy of MRI combined with serum CENPU and HSP90α levels in the diagnosis of breast cancer were 98.60％,63.10％and 85.46％,respectively;the diagnosis results of breast cancer by the combination of the three methods were in good agreement with the pathological diagnosis results(Kappa=0.664,P＜0.05);the sensitivity and accuracy of MRI combined with serum CENPU and HSP90α levels in the diagnosis of breast cancer were obviously higher than those of MRI,CENPU and HSP90αalone(P＜0.05).Conclusion MRI combined with serum CENPU and HSP90α has important clinical value in the diagnosis of breast cancer.
Magnetic Resonance ImagingCentromere Protein UHeat-shock Protein 90αBreast CancerDiagnosis
万方数据
维普
