The Application Value of Serum DKK1,FGF19 Combined with CT in Evaluating the Efficacy of Interventional Therapy in Patients with Primary Hepatic Carcinoma
Objective To explore the value of serum Dickkopf-1(DKK1),fibroblast growth factor 19(FGF19)combined with computed tomography(CT)in evaluating the efficacy of transcatheter arterial chemoembolization(TACE)in patients with primary hepatic carcinoma(PHC).Methods A total of 136 PHC patients in our hospital from January 2022 to February 2023 were included.After 2 months of TACE treatment,they were grouped into an inactivated group(59 cases)and a residual group(77 cases)based on their efficacy.The double antibody sandwich method was applied to detect serum DKK1 and FGF19 levels,and CT scans were performed on patients.ROC curve was applied to obtain the optimal cutoff values for the efficacy of TACE treatment in diagnosing PHC patients with serum DKK1 and FGF19.Using digital subtraction angiography(DSA)as the gold standard,the diagnostic value of serum DKK1,FGF19 combined with CT scan for the efficacy of TACE treatment was explored.Kappa test was applied to analyze the consistency between the efficacy of serum DKK1,FGF19 combined with CT in diagnosing PHC and DSA results.Results The serum levels of DKK1 and FGF19 in the residual group were(2.41±0.33)ng/mL and(206.72±21.60)pg/mL,respectively,which were obviously higher than those in the inactivated group(1.87±0.29)ng/mL and(169.57±18.45)pg/mL(P＜0.05).The ROC curve showed that the area under the curve for diagnosing the efficacy of TACE treatment in PHC patients with serum DKK1 and FGF19 levels was 0.925 and 0.916,respectively,with sensitivity of 83.12％and 84.42％,specificity of 91.52％and 94.92％.CT scan evaluation of TACE treatment efficacy in PHC patients showed high consistency with DSA results,with Kappa value=0.766(P＜0.05).The accuracy of serum DKK1,FGF19 combined with CT scan in diagnosing efficacy was 93.38％,and the sensitivity and specificity were 96.10％and 89.83％,respectively,the sensitivity of the combined detection was obviously better than that of single DKK1,FGF19,and CT scan(P＜0.05).Conclusion The combination of serum DKK1 and FGF19 with CT scan has certain diagnostic value for the efficacy of TACE treatment in PHC patients.
万方数据
维普
