The Role of MRI Combined with Serum TSGF and NDRG4 in The Diagnosis of Epithelial Ovarian Cancer
Objective To investigate the expression of tumor specific growth factor(TSGF)and N-Myc downstream regulator gene 4(NDRG4)in serum of epithelial ovarian cancer and the role of combined magnetic resonance imaging(MRI)in the diagnosis of epithelial ovarian cancer.Methods Sixty patients with epithelial ovarian cancer(ovarian cancer group)who underwent surgery in our hospital from January 2021 to August 2022 were collected as research subjects,meantime,60 patients with gynecological benign tumor(benign group)and 60 healthy people(control group)were selected,which were consistent with the clinical data of patients with epithelial ovarian cancer.The levels of serum TSGF and NDRG4 in each group were compared;receiver operating characteristic was applied to analyze the diagnostic efficacy of serum TSGF and NDRG4 for epithelial ovarian cancer;four grid table method were applied to analyze the diagnostic efficacy of MRI combined with serum TSGF and NDRG4 in epithelial ovarian cancer.Results The serum TSGF level in the ovarian cancer group was obviously higher than that in the benign and control groups(P＜0.05),and the serum NDRG4 level was obviously lower than that in the benign and control groups(P＜0.05);the serum TSGF level in the benign group was obviously higher than that in the control group(P＜0.05),while the serum NDRG4 level was obviously lower than that in the control group(P＜0.05).The accuracy,sensitivity,and specificity of MRI combined with serum TSGF and NDRG4 in diagnosing epithelial ovarian cancer were 93.33％,95.00％,and 91.67％,respectively.Among them,the specificity of the three combined diagnoses was higher than that of NDRG4 and MRI alone(P＜0.05),and the accuracy and sensitivity of the three combined diagnoses were higher than those of TSGF and NDRG4 alone(P＜0.05).Conclusion The expression level of serum TSGF is obviously increased in patients with epithelial ovarian cancer,while the expression level of NDRG4 is obviously reduced.MRI combined with serum TSGF and NDRG4 has certain diagnostic value for epithelial ovarian cancer.
Magnetic Resonance ImagingTumor Specific Growth FactorN-Myc downstream regulator gene 4Epithelial Ovarian CancerDiagnosis
万方数据
维普
