目的 探讨绝经后骨质疏松症(osteoporosis,OP)患者皮质骨孔率、形态结构、矿化和类骨质密度MRI指标是否受到影响,并探讨MRI指标与绝经后妇女骨密度(BMD)的关系.方法 回顾性分析本院于2021年6月到2023年6月期间收治的30名OP患者和38名非OP患者的临床资料.在1.5T时,对皮质骨孔率(孔隙水和总水)、类骨质密度(结合水[BW])、形态结构(皮质骨厚度)和矿化(磷[P]密度[31P]和31P/BW浓度比)进行量化,比较OP组和非OP组之间的MRI测量结果,并评估其与BMD的相关性.结果 OP组的骨质疏松症患者骨密度明显高于非OP组(11.6mol/L vs 9.5mol/L;P=0.007;P=0.007),总水密度(21.2mol/L vs 19.7mol/L;P=0.03),骨皮质厚度(4.8mm vs 5.6 mm;P＜0.001)和31P密度(6.4mol/L vs 7.5mol/L;P=0.01)明显低于非OP组.孔隙密度和总水密度与DXA和外周定量CT骨密度呈负相关(P＜0.001),而皮质骨厚度和31P密度与DXA和外周定量CT BMD呈正相关(P=0.01).BW、31P密度、31P/BW浓度比与DXA呈正相关(P＜0.05),与外周定量CT无关.结论:皮质骨的固态MRI能够帮助检测绝经后骨质疏松症中反映孔洞、形态结构和矿化的参数的潜在损害.
Quantitative MRI Study on Cortical Bone Porosity,Mineralization,and Morphological Structure in Postmenopausal Osteoporosis
Objective To investigate whether the cortical bone porosities,morphological structure,mineralization and Osteoid density in postmenopausal osteoporosis(OP)patients were affected by MRI,and to explore the relationship between MRI and bone mineral density(BMD)in postmenopausal women.Methods A retrospective analysis was conducted on the clinical data of 30 OP patients and 38 non OP patients admitted to our hospital from June 2021 to June 2023.At 3.0T,the cortical bone porosity(pore water and total water),Osteoid density(bound water[BW]),morphological structure(cortical bone thickness)and mineralization(phosphorus[P]density[31P]and 31P/BW concentration ratio)were quantified,the MRI measurement results between OP group and non OP group were compared,and their correlation with BMD was evaluated.Results The bone density of osteoporosis patients in the OP group was significantly higher than that in the non OP group(11.6mol/L vs 9.5mol/L;P=0.007;P=0.007),total water density(21.2mol/L vs 19.7mol/L;P=0.03),bone cortex thickness(4.8 mm vs 5.6 mm;P＜0.001),and 31P density(6.4mol/L vs 7.5mol/L;P=0.01),which were significantly lower than those in the non OP group.Pore density and total water density were negatively correlated with DXA and peripheral quantitative CT bone density(P＜0.001),while cortical bone thickness and 31P density were positively correlated with DXA and peripheral quantitative CT BMD(P=0.01).BW,31P density,and 31P/BW concentration ratio were positively correlated with DXA(P＜0.05),but not with peripheral quantitative CT.Conclusion Solid state MRI of cortical bone can help detect potential damage to parameters reflecting pores,morphological structure,and mineralization in postmenopausal osteoporosis.
Postmenopausal OsteoporosisCortical Foramen RateOsteoporosis MineralizationMRI Quantitative Research
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维普
