Imaging Manifestations and Research Progress of Human Epidermal Growth Factor Receptor2 Positive Gastric Cancer
Gastric cancer is one of the most common malignant tumors in the digestive system.The early symptoms are not obvious,and the prognosis is often very poor once found.New therapeutic strategies are urgently needed to improve the prognosis of patients with gastric cancer.Trastuzumab(Monoclonal antibody against human epidermal growth factor receptor 2)combined with chemotherapy can significantly improve the overall survival and prognosis of patients with gastric cancer.The traditional methods for the detection of human epidermal growth factor receptor2 are immunohistochemical staining and fluorescence in situ hybridization of surgical specimens or biopsy specimens,Gastric cancer is highly heterogeneous tumor,and biopsy specimens show only part of the tumor,which can lead to incorrect test results,an increased risk of false negative results,and patients losing the opportunity to target therapy.With the increasing maturity of medical technology,more and more clinical trials begin to explore the value of non-invasive imaging methods in identifying human epidermal growth factor receptor2 expression.This review documents the value of noninvasive imaging in evaluating human epidermal growth factor receptor2 positive gastric cancer.
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