Diagnostic and Prognostic Value of Serum PCSK9,ANGPTL4 Combined with Quantitative Parameters of Carotid Ultrasound in Acute Cerebral Infarction
Objective To explore the diagnostic and prognostic value of serum preprotein convertase subtilisin/kexin type 9(PCSK9),angiopoietin-like protein 4(ANGPTL4)combined with carotid ultrasound quantitative parameters for acute cerebral infarction(ACI).Methods A total of 108 patients with ACI who were treated in our hospital from July 2021 to July 2022 were selected as the ACI group,including 60 patients with good prognosis and 48 patients with poor prognosis.102 healthy volunteers who were examined in our hospital were regarded as the control group.The levels of serum PCSK9 and ANGPTL4 were detected by enzyme-linked immunosorbent assay(ELISA);Pearson method was applied to analyze the correlation between the expression levels of serum PCSK9 and ANGPTL4.All subjects were examined by color Doppler ultrasound,including end-diastolic blood flow velocity(EDV),carotid intima-media thickness(IMT)and peak systolic blood flow velocity(PSV).The diagnostic and prognostic value of serum PCSK9,ANGPTL4 combined with quantitative parameters of carotid artery ultrasound in ACI was analyzed by ROC curve.Results Compared with the control group,the level of PCSK9 in ACI group was obviously higher and the level of ANGPTL4 was obviously lower(P＜0.05).Correlation analysis showed that the levels of PCSK9 and ANGPTL4 in serum of ACI patients were negatively correlated(r=-0.338,P＜0.001).Compared with the control group,the levels of EDV and IMT in ACI group were obviously higher,while the level of PSV was obviously lower(P＜0.05).Compared with the good prognosis group,the levels of PCSK9,EDV and IMT in the poor prognosis group were obviously higher,and the levels of ANGPTL4 and PSV were obviously lower(P＜0.05).The AUCROC value of serum PCSK9,ANGPTL4 combined with carotid ultrasound quantitative parameters in the diagnosis and prognosis of ACI was higher than the AUCROC value measured by each index alone(P＜0.05).Conclusion PCSK9 is highly expressed and ANGPTL4 is low in serum of patients with ACI.The combination of PCSK9 and ANGPTL4 with quantitative parameters of carotid ultrasound has diagnostic and prognostic value for ACI.
Acute Cerebral InfarctionPreprotein Convertase Subtiliisin/Kexin Type 9Angiopoietin-like Protein 4DiagnosisPrognosis
NETL
NSTL
万方数据
维普
