Value of MRI Multi-sequence Scanning in the Diagnosis of Primary Temporal Lobe Epilepsy
Objective To explore the value of magnetic resonance imaging(MRI)multi-sequence scanning in diagnosing primary temporal lobe epilepsy(TLE).Methods 50 patients with primary TLE admitted to Zhumadian Central Hospital from January 2022 to Aguest 2023 were selected as observation group,and 50 healthy volunteers during the same period were included in control group,and the above subjects underwent MRI multi-sequence scanning.The regions of interest(ROI)of the apparent diffusion coefficient(ADC),fractional anisotropy(FA),cerebral blood flow(CBF),N-acetylaspartate/creatine ratio(NAA/Cr)and choline/creatine ratio(Cho/Cr)were detected in the two groups,and the clinical value of various parameters and their combination in the diagnosis of primary TLE was analyzed.Results The ADC value in observation group was higher than that in control group(P＜0.05)while the FA value and NAA/Cr value were lower than those in control group(P＜0.05).The CBF values of right hippocampus,left hippocampus,right amygdala and left amygdala and overall mean value in observation group were higher than those in control group(P＜0.05).There was no statistical significance in Cho/Cr between the two groups(P＞0.05).When the Youden index of ADC value was the largest,the corresponding cutoff value,AUC,sensitivity and specificity were 0.96x10-3 mm2/s,0.700,74.00％and 78.00％.When the Youden index of FA value was the largest,the cutoff value,AUC,sensitivity and specificity were 0.30,0.671,86.00％and 78.00％.When the Youden index of overall mean value of CBF was the largest,the corresponding cutoff value was 56.02 ml/100g/min and the AUC,sensitivity and specificity were 0.769,84.00％and 82.00％.When the Youden index of NAA/Cr value was the largest,the cutoff value,AUC,sensitivity and specificity were 1.74,0.717,86.00％and 68.00％.The combination of the four had the highest value in the diagnosis of medial temporal lobe epilepsy(mTLE),with AUC of 0.811,sensitivity of 94.00％and specificity of 64.00％.Conclusion The combined detection with ADC,FA,CBF and NAA/Cr has higher accuracy in the diagnosis of mTLE than the single use of any of the four indicators,which is of high clinical value and worthy of promotion.
NETL
NSTL
万方数据
维普
