A Resting-state Functional Magnetic Resonance Imaging Study of Temporal Lobe Epilepsy with Executive Dysfunction
Objective To observe the functional connectivity(FC)of thalamus-dorsolateral prefrontal pathway in patients with temporal lobe epilepsy showing executive dysfunction by using functional magnetic resonance imaging.Methods Thirty-two patients with temporal lobe epilepsy were analyzed retrospectively,and the differences of FC and hippocampus volume between thalamus and dorsolateral prefrontal cortex among patients with normal executive function,patients with executive dysfunction and healthy controls were compared,and the correlation between these parameters with significant differences and Wisconsin Card Sorting Test(WCST)was observed.Results The temporal lobe epilepsy patients with executive control dysfunction showed decreased FC between thalamus and dorsolateral prefrontal lobe pathway,which was significantly related to executive function performance.There is no significant correlation between hippocampal volume and executive function.Conclusion The dorsal lateral prefrontal-thalamic connection pathway may be an important feature to measure the executive function of patients with temporal lobe epilepsy.
Temporal Lobe EpilepsyFunctional Magnetic Resonance ImagingExecutive DysfunctionFunctional ConnectionHippocampus
NETL
NSTL
万方数据
维普
