Application Value of MSCT Combined with Serum CCNA2 and AFP in the Differential Diagnosis of Cirrhosis Nodule and Hepatocellular Carcinoma
Objective To explore the application value of multi-slice spiral computed tomography(MSCT)combined with serum cyclin A2(CCNA2)and alpha-fetoprotein(AFP)in the differential diagnosis of cirrhosis nodule and hepatocellular carcinoma.Methods 104 patients with liver cirrhosis nodules and hepatocellular carcinoma confirmed by pathology admitted to our hospital from January 2019 to January 2022 were selected,including 69 cases of liver cirrhosis nodules and 35 cases of hepatocellular carcinoma.All patients underwent abdominal MSCT plain and enhanced scans to detect serum CCNA2 and AFP levels.Analyze the MSCT imaging features of patients with liver cirrhosis nodules and hepatocellular carcinoma,as well as the serum levels of CCNA2 and AFP in the liver cirrhosis nodule group and hepatocellular carcinoma group;Draw receiver operating characteristic(ROC)curves to analyze the application value of MSCT combined with serum tumor markers in distinguishing liver cirrhosis nodules from hepatocellular carcinoma.Results In the 104 patients,pathological examination showed that there were 69 cases in cirrhosis nodule group and 35 cases in hepatocellular carcinoma group.Taking pathological results as the golden standard,the sensitivity and specificity of MSCT in the differential diagnosis of hepatocellular carcinoma were 77.14％and 75.36％(Kappa=0.493).The levels of serum CCNA2 and AFP in hepatocellular carcinoma group were significantly higher than those in cirrhosis nodule group(P＜0.05).The results of ROC curves analysis showed that area under the curve(AUC)values of MSCT,serum CCNA2 and AFP for predicting hepatocellular carcinoma were 0.886,0.836 and 0.775,respectively.AUC and sensitivity of MSCT combined with serum CCNA2 and AFP for predicting hepatocellular carcinoma were 0.902 and 82.86％(P＜0.05).Conclusion MSCT combined with serum CCNA2 and AFP has high clinical application value in the differential diagnosis of cirrhosis nodules and hepatocellular carcinoma.
NETL
NSTL
万方数据
维普
