Correlation between MRI Imaging Findings and Angiogenesis and Prognostic Factors of Primary Liver Cancer
Objective To investigate the correlation between MRI imaging findings and angiogenesis and clinicopathological features of primary liver cancer,and to analyze the factors affecting the diagnosis,treatment and prognosis of liver cancer.Methods A total of 286 patients with primary liver cancer who underwent surgery and pathology in our hospital from January 2020 to January 2022 were selected.All patients underwent preoperative MRI imaging examination,and the vascular endothelial growth factor(VEGF)and microvascular density(MVD)in their plasma were quantitatively detected by ELISA.The clinicopathological data were compared statistically,analyzed,modeled and verified.Results All patients completed MRI scan.MRI evaluation results showed that the liver cancer was mainly characterized by high T2 signal intensity,and the signal intensity of liver cancer was different in Ti-weighted imaging.The lesions showed burr and nodular enhancement effects.The results of MRI tumor image parameters of primary liver cancer showed:Among the 286 patients with primary liver cancer,66.43％had capsule,70.98％had tumor size ≥3 cm,63.29％had tumor vessels,and 78.32％had tumor necrosis.Multiple nodules accounted for 81.47％,portal vein cancer suppositories accounted for 23.08％,cirrhosis accounted for 24.83％.The consistency test results of MRI texture features of primary liver cancer showed that the consistency of focal delineation was good in 286 patients with primary liver cancer(ICC＞0.80,P＜0.01).MRI tumor imaging features of primary liver cancer(capsule,tumor size,tumor vessel,tumor necrosis,tumor number,portal vein cancer thrombin,cirrhosis,texture parameters)has been associated with angiogenesis(VEGF,MVD),emphasemphasised is_angle45_offset8(P＜0.05).The results of follow-up showed that 114 cases(39.86％)had recurrence/metastasis and 172 cases(60.14％)had no metastasis/recurrence.After 18 months of follow-up,49 cases died.The manifestations of envelope,tumor size,portal vein thrombus,cirrhosis and texture parameters were correlated with the prognosis of hepatocellular carcinoma(P＜0.05).Tumor size,portal vein tumor thrombus,cirrhosis,capsule and smaller texture parameters were the influencing factors of recurrence/metastasis in patients with primary liver cancer(P＜0.05).The results of the Hosmer-Lemeshow test showed x 2=2.277 and P=0.864,indicating a good fit between the model and the observed values.ROC analysis results showed that the AUC of Logistic regression model for predicting early postoperative HCC recurrence was 0.847,and 95％CI was 0.754～0.905,indicating that the model had good predictive efficacy(P＜0.05).Conclusion MRI tumor imaging findings can well reflect the pathological changes of primary liver cancer,VEGF and MVD changes are closely related to the diagnosis,treatment and prognosis of liver cancer,which is a valuable biomarker.
NETL
NSTL
万方数据
维普
