Diagnostic Value of MRI-ECV Combined with MRI-PDFF Imaging for Early Liver Fibrosis in a NAFLD Cynomolgus Model
Objective To investigate the diagnostic value of magnetic resonance extracellular volume fraction(ECV)and proton density fat fraction(PDFF)in cynomolgus monkey model of nonalcoholic fatty liver disease(NAFLD).Methods 104 cynomolgus monkeys(F1 group)with early liver fibrosis(stage F1)were confirmed by liver puncture pathology and 10 normal cynomolgus monkeys(normal group)were included for abdominal T1 mapping and PDFF imaging.The liver magnetic resonance extracellular volume fraction(MRI-ECV)and the fat fraction of the two groups were compared.Results the MRI-ECV and PDFF value in the F1 group were higher than those in the normal group,and there was significant difference between the two groups(PECV＜0.001,PPDFF＜0.001).There was a moderate correlation between MRI-ECV and MRI-PDFF with NAS scores of liver(rECV-lobular inflammation=0.432 P＜0.001,rPDFF-steatosis=0.628 P＜0.001),demonstrating good diagnostic efficacy in liver fibrosis and fat assessment.Conclusion MRI-ECV combined with MRI-PDFF has great potential for quantitative evaluation of early liver fibrosis and fat fraction in NAFLD cynomolgus monkey model.
Extracellular Volume FractionProton Density Fat FractionLiver FibrosisNonalcoholic Fatty Liver DiseaseCynomolgus
NETL
NSTL
万方数据
维普
