Analysis of Diagnostic Efficacy of Serum PSA Combined with Biparametric Magnetic Resonance Imaging for Prostate Cancer
Objective To analyze the value of biparametric magnetic resonance imaging(bpMRI)combined with serum prostate specific antigen(PSA)in the diagnosis of prostate cancer.Methods Clinical data of patients with prostate diseases in the pathology database of our hospital were retrospectively collected and analyzed.According to the pathological examination results,they were grouped into 126 cases of prostate cancer(prostate cancer group)and 104 cases of benign prostatic hyperplasia(reference group).All patients underwent biparametric MRI examination before surgery,chemiluminescence immunoassay was applied to quantitatively detect serum PSA level;ROC curve was plotted to analyze the diagnostic value of different indicators;Kappa consistency test was applied to analyze the consistency between different indicators and pathological results.Results The serum PSA level in the prostate cancer group was obviously higher than that in the reference group(P＜0.05).The Kappa values of T2WI and DWI compared with pathological results were 0.679 and 0.703,respectively(P＜0.05).The AUC of biparametric MRI,PSA alone and in combination for diagnosing prostate cancer was 0.893,0.772,and 0.955,respectively(P＜0.05).The Kappa values of biparametric MRI,PSA,and combined examination compared with pathological results were 0.775,0.475,and 0.895,respectively(P＜0.05).The accuracy,sensitivity,and negative predictive value of biparametric MRI combined with serum PSA in differential diagnosis of prostate cancer were obviously higher than those of the two individual diagnoses,while the specificity and positive predictive value were obviously higher than those of serum PSA individual diagnoses(P＜0.05).Conclusion biparametric MRI,PSA all have certain diagnostic efficacy for prostate cancer,and their combination can further improve diagnostic value,which can be considered for clinical promotion.
Prostate CancerDual Parameter Magnetic Resonance ImagingProstate Specific AntigenDiagnosis
NETL
NSTL
万方数据
维普
