The Value of Enhanced T2-FLAIR ADC in the Differential Diagnosis of Primary Central Nervous System Lymphoma and High-grade Glioma
Objective To investigate the valuation of ADC value of peritumoral edema area in differentiating primary central nervous system lymphoma(PCNSL)from high-grade glioma(HGG)referring to enhanced T2-FLAIR.Methods In this study,16 patients with PCNSL and 34 patients with HGG confirmed by pathology were retrospectively included.Independent sample t-test was used to compare the age between the two groups.Apparent diffusion coefficient(ADC)value was measured in the peritumoral edema area referring to enhanced T2-FLAIR.Receiver operator characteristiccurve(ROC)curve was used to analyze the differential diagnosis valuation of ADC value.Results There was no statistically significant difference between the age of PCNSL and HGG(t=-0.726,P＞0.05).There was statistically significant difference between the ADC value in peritumoral edema area of two groups(P＜0.01).The ADC value of PCNSL[(1.60±0.24)×10-3mm2/s]was higher than that of HGG[(1.34±0.16)×10-3mm2/s](t=-4.438,P=0.000).The area under ROC curve was 0.809mm2,with 1.54×103mm2/s as cut-off value,the sensitivity,specificity were 75％,93.7％,respectively.Conclusion The ADC values of peritumoral edema area referring to enhanced T2-FLAIR can effectively differentiate PCNSL from HGG.
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