Correlation Analysis of CT Perfusion Imaging,Serum CRP and ET-1 Levels with the Severity and Prognosis of Acute Ischemic Stroke Patients
Objective To explore the correlation between CT perfusion imaging,serum C-reactive protein(CRP)and endothelin-1(ET-1)levels and the severity and prognosis of acute ischemic stroke(AIS)patients.Methods A total of 150 AIS patients treated in our hospital from January 2021 to December 2022 were collected as the study group,and another 150 healthy subjects in the same period were collected as the control group.The characteristics of CT perfusion imaging on admission were compared in the study group,and the CT perfusion imaging parameters and serum CRP and ET-1 levels were compared between the two groups.CT perfusion imaging parameters and serum CRP and ET-1 levels of patients with different degrees of neurological impairment at the time of hospitalization were further compared,and the correlation between the above data and NIHSS score was analyzed.The prognosis of AIS patients was evaluated according to the modified Rankin scale(mRS)[1]3 months after treatment.The study group could be divided into good prognosis(n=114).Two subgroups with poor prognosis(n=36)were compared with CT perfusion imaging parameters and serum CRP and ET-1 levels at admission of the two groups,and ROC curve was used to analyze the predictive value of the above parameters in predicting poor prognosis of AIS patients.Results The levels of CRP,ET-1,MTT,TTP and DT in the study group were higher than those in the control group,but the values of CBF and CBV were lower than those in the control group(P＜0.05).Compared with those with mild neurological impairment,serum CRP,ET-1,MTT,TTP and DT values were increased in patients with severe and severe neurological impairment,while CBF and CBV values were decreased(P＜0.05).The levels of CRP,ET-1,MTT,TTP and DT were positively correlated with NIHSS,while the values of CBF and CBV were negatively correlated with NIHSS(P＜0.05).The levels of CRP,ET-1,MTT,TTP and DT in patients with good prognosis were significantly lower than those with poor prognosis,while the values of CBF and CBV were higher than those with poor prognosis(P＜0.05).The AUC of combined prediction was 0.871,the best prediction sensitivity was 94.44％,and the specificity was 79.82％,which were higher than that of single diagnosis(P＜0.05).Conclusion CT perfusion imaging,serum CRP and ET-1 levels are closely related to the severity of AIS patients,and combined detection has certain predictive value for AIS patients.
Acute Ischemic StrokeCT Perfusion ImagingC-reactive Proteinthe Degree of IllnessPrognostic ValueCorrelation
万方数据
维普
