Application of DTI Combined with MAGiC for Parkinson's Disease in Multimodal Magnetic Resonance Functional Imaging
Objective To evaluate the diagnostic value of the diffusion tensor imaging(DTI)sequence and magnetic resonance image complication(MAGIC)sequence in multimodal magnetic resonance imaging(MRI)for Parkinson's disease(PD).Methods A total of 31 PD patients and 25 healthy control patients were included in the study from June 2019 to June 2021,and were scanned using the 3.0T GE Pioneer model at our hospital.T1MAP,T2MAP,PDMAP,and fractional anisotropy(FA)values were recorded in the putamen,caudate head,substantia nigra,parahippocampal gyrus,and temporal lobe.ROI selection,mapping,data statistics,and analysis were conducted on the MAGiC and DTI sequences of the subjects.Results The MAP values of T1MAP in the putamen,parahippocampal gyrus(left),and temporal lobe,T2MAP in the putamen(left),caudate nucleus(right),parahippocampal gyrus(left),and PDMAP in the parahippocampal gyrus(left),were lower in PD patients than in the healthy control group,with statistical significance(P＜0.05).The ROC analysis showed that the diagnostic AUCs of T1MAP in the parahippocampal gyrus and temporal lobe were 0.812 and 0.821,respectively,that of T2MAP was 0.73 and 0.786,and that of FA was 0.338 and 0.332.Therefore,the diagnostic value of the temporal lobe was higher than that of the parahippocampal gyrus,and the diagnostic value of T1MAP was higher than that of T2MAP and FA.Conclusion The combination of MAGIC and DTI sequences in multimodal MRI showed higher diagnostic efficacy for PD in the temporal lobe than in the parahippocampal gyrus,and T1MAP was found to be more effective than T2MAP and FA.
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