Imaging Characteristics of Liver-brain Functional Area rfMRI and Its Correlation in Patients with Depression
Objective To investigate the imaging features of liver-brain functional area by resting state functional magnetic resonance imaging(rfMRI)and its correlation in patients with depression.Methods From November 2022 to July 2023,40 patients with depression diagnosed in the psychiatric outpatient department of the hospital were divided into mild to moderate group and severe group according to the severity of the disease,rfMRI was used to record the imaging information of the brain region,and the imaging characteristics of the liver-brain function region of the mild to moderate group and the severe group were compared.During the same period,20 healthy volunteers who underwent physical examination in hospitals were selected as controls to compare the imaging characteristics of liver-brain functional regions between healthy volunteers and depressed patients,Pearson correlation analysis evaluated the correlation between abnormal imaging characteristics of liver-brain functional regions and depression.Results The ReHo value of left middle occipital gyrus in mild-moderate group was lower than that in severe group,and the ReHo value of bilateral anterior cuneus,middle cingulate gyrus and amygdala was higher than that in severe group,with statistical significance(P＜0.05).The ReHo value of left middle occipital gyrus in healthy volunteers was lower than that of depressed patients,and the ReHo value of bilateral anterior cuneus,middle cingulate gyrus and amygdala was higher than that of depressed patients,with statistical significance(P＜0.05).The results of Pearson correlation analysis showed that the ReHo value of the left medial occipital gyrus in the hepato-brain functional region was positively correlated with HAMD-24 scores(r=0.506,P＜0.05),The ReHo values of the right anterior cuneus,left anterior cuneus,right middle cingulate gyrus,left middle cingulate gyrus,right amygdala,and left amygdala were negatively correlated with HAMD-24 scores(r=-0.446,-0.452,-0.462,-0.481,-0.520,-0.531,P＜0.05).Conclusion The abnormal changes of liver-brain function in depressed patients were distributed in the anterior cuneus,middle occipital gyrus,middle cingulate gyrus and amygdala,and with the progression of depression,the ReHo value of the middle occipital gyrus gradually increased,and the ReHo value of the anterior cuneus,middle cingulate gyrus and amygdala gradually decreased,the abnormalities of the middle occipital gyrus,anterior cuneus,middle cingulate gyrus and amygdala have correlation in patients with depression.
DepressionLiver-brain Functional AreaResting State Functional Magnetic Resonance imagingCorrelation
万方数据
维普
