Value of Low Dose CT Combined with Peripheral Blood Circulating Tumor Cells in Early Diagnosis of Lung Cancer
Objective To explore the value of low dose CT combined with peripheral blood circulating tumor cells(CTCS)in the early diagnosis of lung cancer.Methods 75 patients with early stage lung cancer admitted to our hospital from December 2019 to December 2022 were selected as lung cancer group.In the same period,59 patients with benign lung lesions treated with our hospital were selected as the control group.Clinical data of patients in both groups were collected.All patients underwent low-dose CT scanning and CTC levels were detected.Logistic regression analysis was performed to determine the factors affecting the occurrence of lung cancer,and the predictive value of low-dose CT and CTC detection in the early diagnosis of lung cancer was analyzed according to receiver operating characteristic(ROC)curve.Results The number of patients with lobular sign,burr sign and pleural sag sign in lung cancer group was higher than that in control group(P＜0.05).The number of patients with smoking history,positive low-dose CT and positive CTCS in lung cancer group was higher than that in control group(P＜0.05).Logistic regression analysis showed that smoking history,positive burr sign,pleural depression sign and positive CTCS were independent risk factors for lung cancer(P＜0.05).ROC analysis showed that the value of AUC for diagnosing early lung cancer was 0.747 and 95％CI was 0.664～0.818.The AUC value of pleural depression sign was 0.789,and 95％CI was 0.710-0.854.The AUC value predicted by CTC was 0.840,and 95％CI was 0.767-0.898.The combined predicted AUC value was 0.878,and 95％CI was 0.811-0.928.Conclusion The low-dose CT findings of lobular sign,pleural depression sign and CTC are of certain reference value for the early diagnosis of lung cancer,and the combination of the three is of higher value for the early diagnosis of lung cancer.
万方数据
维普
